Test system for in-vitro detection of an antigen-specific...

Details Test system for in-vitro detection of an antigen-specific... Test system for in-vitro detection of an antigen-specific...

G - Physics

01

N

G01N 33/50 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2375191

The present invention relates to a test system, which comprises at least one capsomer, at least one stable capsomer, at least one capsid, at least one VLP and/or at least one CVLP, and at least one antigen-presenting target cell, in particular B cell, macrophage, predendritic cell, dendritic cell, embryonic cell and/or fibroblast, which has been incubated with at least one capsomer, at least one stable capsomer, at least one capsid, at least one VLP and/or at least one CVLP, for the in-vitro detection of an antigen-specific immune response, in particular cellular immune response of effector cells of the immune system, in particular B cells, NK cells, preferably T cells, in a particularly preferred manner cytotoxic T cells or T helper cells, and to their use in diagnosis and therapy.

L'invention concerne un système de test comprenant au moins un capsomère, au moins un capsomère stable, au moins un capside, au moins un VLP, et/ou au moins un CVLP, et au moins une cellule cible présentant un antigène. La cellule cible est en particulier du type cellule B, macrophage, cellule prédendritique, cellule dendritique, cellule embryonnaire, et/ou fibroblaste, et a été incubée avec au moins un capsomère, au moins un capsomère stable, au moins un capside, au moins un VLP, et/ou au moins un CVLP, pour la détection in vitro d'une réaction immunitaire antigène spécifique. La réaction immunitaire est en particulier du type réaction immunitaire cellulaire de cellules effectrices du système immunitaire ; en particulier cellules B, cellules NK, de façon préférentielle cellules T et surtout cellules T cytotoxiques ou cellules T </= helper >/= . L'invention concerne également l'application en diagnostic et thérapie.

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