Tet-transactivator system

Details Tet-transactivator system Tet-transactivator system

C - Chemistry, Metallurgy

12

N

C12N 15/66 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 39/002 (2006.01) A61K 39/015 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2377608

A transcriptional activator of T. gondii is provided which comprises the tetracycline repressor (TetR) operatively linked to a transacting factor of T. gondii. Strains of T. gondii transformed with a vector containing such a transactivator may be used to . prepare vaccine compositions or to identify essential genes in the parasite. The system provided may be useful in other Apicomplexan species such as Plasmodium falciparum, Plasmodium vivax, Plasmodium berghei, Plasmodium yoelii, Plasmodium knowlesi, Trypanosoma brucel, Entamoeba histolytica, and Giardia lambia.

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