Tetra-aza macrocycles and processes for their preparation

Details Tetra-aza macrocycles and processes for their preparation Tetra-aza macrocycles and processes for their preparation

C - Chemistry, Metallurgy

07

F

260/237.2

C07F 9/547 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07F 9/6524 (2006.01)

Patent

CA 2026322

2026322 9009388 PCTABS00001 Tetra-aza macrocycles of formula (I), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; d is zero or an integer 1, 2 or 3; q is zero or an integer from 1 to 6 inclusive; R, R1, R2 and R3, which may be the same or different, is each a hydrogen atom or a group -P(O)(XH)R4 (where X is an oxygen or sulphur atom and R4 is a hydrogen atom or an alkyl or alkoxy group), with the proviso that at least one of R, R1, R2 and R3 is a -P(O)(XH)R4 group; L is a covalent bond or a linker group; Z is a hydrogen atom or a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and may be coupled to other molecules, such as proteins for use in diagnosis and therapy.

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