C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6524 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07D 257/02 (2006.01)
Patent
CA 2057868
2057868 9116081 PCTABS00007 Metal complex of tetra-aza macrocycles of formula (1) wherein Alk1, Alk2, Alk3 and Alk4, which may be the same or different, is each a C1-4 alkylene chain optionally substituted by one or more optionally substituted C1-6 alkyl groups; and R1, R2, R3 and R4 which may be the same or different is each a hydrogen atom or a group AlkR5 where Alk is an optionally substituted straight or branched C1-6 alkyl group and R5 is a hydrogen atom or a -CO2H,-CONR6R7 [where R6 and R7, which may be the same or different, is each a hydrogen atom or a C1-6 alkyl group] or -P(X1)(X2R8)R9 group where X1 and X2, which may be the same or different is each an oxygen or sulphur atom, R8 is a hydrogen atom or an alkyl group and R9 is an aliphatic, aromatic or heteroaromatic group, with the proviso that at least two of R1, R2, R3 and R4 is a group -AlkP(X1)(X2R8)R9 or one of R1, R2, R3 and R4 is a group -AlkP(X1)(X2R8)R9 and at least one of the remaining groups R1, R2, R3 and R4 is a group -AlkCO2H or -AlkCONR6R7, or a salt thereof, for use as contrast agents in nuclear magnetic resonance imaging are described.
Beeley Nigel Robert Arnold
Parker David
Celltech Therapeutics Limited
Kirby Eades Gale Baker
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