Tetra-cyclic carboline derivatives for inhibiting angiogenesis

Details Tetra-cyclic carboline derivatives for inhibiting angiogenesis Tetra-cyclic carboline derivatives for inhibiting angiogenesis

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2559545

In accordance with the present invention,tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

Selon l'invention, des composés qui inhibent l'expression de VEGF après transcription, ont été identifiés, et l'invention a pour objet des procédés pour les utiliser. Un aspect de l'invention concerne des composés utiles pour inhiber la production de VEGF, pour inhiber l'angiogenèse, et/ou pour traiter le cancer, la rétinopathie diabétique ou la dégénérescence maculaire exsudative. Un autre aspect de l'invention concerne des procédés pour inhiber la production de VEGF, inhiber l'angiogenèse et/ou traiter le cancer, la rétinopathie diabétique ou la dégénérescence maculaire exsudative au moyen desdits composés.

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