Tetracyclic anthraquinone antibiotic derivatives with high...

Details Tetracyclic anthraquinone antibiotic derivatives with high... Tetracyclic anthraquinone antibiotic derivatives with high...

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 31/704 (2006.01) A61K 31/7042 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2721140

The present invention relates to tetracyclic anthraquinone antibiotic derivatives with anticancer activity. The tetracyclic anthraquinone antibiotic derivatives as provided in the present invention have the same or higher activity than that of the known drugs such as doxorubicin, daunorubicin and the like in the cellular level while having better tolerance than that of doxorubicin and daunorubicin in the animal body.

L'invention porte sur des dérivés antibiotiques d'anthracycline ayant une activité anticancéreuse, à savoir sur les composés de formule I. Les présents dérivés antibiotiques d'anthracycline ont la même activité ou une activité supérieure à celle des médicaments connus tels que la doxorubicine et la daunorubicine au niveau cellulaire et en même temps les présents dérivés ont une meilleure tolérance que la doxorubicine dans un corps d'animal.

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