Tetracyclic antibiotics and processes for their preparation

Details Tetracyclic antibiotics and processes for their preparation Tetracyclic antibiotics and processes for their preparation

C - Chemistry, Metallurgy

07

D

C07D 477/00 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 471/14 (2006.01) C07D 491/052 (2006.01) C07D 491/14 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2069764

HOE 91/F 166K ABSTRACT Tetracyclic antibiotics and processes for their prepara- tion .beta.-Lactam antibiotics of the formula I, and their pharma- ceutically tolerable salts Image I where X is (CH2)0-2, CR(a)R(b), O, SO0-2 or NR(c), R(1), R(2) and R(3) are a multiplicity of substituents, are outstanding antibiotics with remarkably good anti- bacterial activity both against gram-positive and against gram-negative microorganisms. They have a high stability to renal dehydropeptidase. They are obtained by cyclization of the compounds II Image II or III Image III

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