Tetracyclic antidepressants

C - Chemistry – Metallurgy – 07 – D

Patent

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167/233, 167/234

C07D 491/044 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1325807

Abstract The invention relates to novel tetracyclic compounds with an anti-depressant action, without neuroleptic or sedative side effects, of the general formula I Image I and also functional derivatives hereof, wherein: R1 represents one or two identical or different sub- stituents denoting H, OH, halogen, C1-C4 alkyl or C1-C4 alkoxy; R2 represents one or two identical or different sub- stituents having the same meaning as R1; R3 and R4 are two substituents which are in the cis con- figuration and of which one is H and the other is OH; R5 is H or C1-C4 alkyl: X denotes O or S; n is 0 or 1.

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