Tetracyclic azepinoindole compounds as 5-ht receptor ligands

Details Tetracyclic azepinoindole compounds as 5-ht receptor ligands Tetracyclic azepinoindole compounds as 5-ht receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 471/16 (2006.01) A61K 31/395 (2006.01) A61P 43/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 223/00 (2006.01) C07D 265/00 (2006.01) C07D 279/00 (2006.01) C07D 498/16 (2006.01) C07D 513/16 (2006.01)

Patent

CA 2367682

The present invention provides compounds of formula (I), wherein R2 is hydrogen, C1-7alkyl, C1-7alkanoyl, arylcarbonyl, aryl, (aryl)C1-7alkyl, C1- 7alkoxycarbonyl, aryloxycarbonyl, arylsulfonyl, or (aryl)C1-7alkoxycarbonyl; X and Y together are 2, 3 or 4 membered saturated or partially unsaturated chain. These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.

La présente invention concerne des composés de la formule (I), dans laquelle R¿2? est hydrogène, C¿1-7?alkyle, C¿1-7?alcanoyle, arylcarbonyle, aryle, (aryl)C¿1-7?alkyle, C¿1-7?alcoxycarbonyle, aryloxycarbonyle, arylsulfonyle, ou (aryl)C¿1-7?alcoxycarbonyle, X et Y étant tous les deux une chaîne saturée ou partiellement insaturée à 2, 3 ou 4 éléments. Ces composés sont des ligands 5-HT utilisés dans les traitements de maladies nécessitant une modulation de l'activité 5-HT.

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