Tetracyclic compounds as c-met inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 487/12 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2529323

The present invention relates to compounds of the Formulae (I) and (II), wherein R1 - R10 and G are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

L'invention concerne des composés de formules (I) et (II), dans lesquelles R¿1? - R¿10? et G sont définis dans la description et les sels acceptables sur le plan pharmaceutique de ceux-ci. Ces composés modulent l'activité de c-Met et sont censés, par conséquent, être utiles dans la prévention et le traitement de troubles relatifs à c-Met, tels que le cancer.

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