C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/5383 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2603274
Formula I compounds with relative trans-configurations: (see formula I), where:.cndot X represents an oxygen atom or an NR2 group, .cndot. Y represents a group selected from -CH2-, -(CH2)2- AND -1CH=CH- , .cndot. R1 and R2 are the same or different, each representing a hydrogen atom or a group selected from alkyl, cycloalkyl, cycloalkylalkyl, in racemic form or optical isomer form, as well as their addition salts with pharmaceutically acceptable acids and their hydrates. The invention also relates to the method for preparing formula I compounds, their use, and the pharmaceutical compositions that contain them.
Composés de formule I, de configuration relative trans : (see formula I) dans laquelle : .cndot. ~X représente un atome d'oxygène ou un groupement NR2, .cndot. ~Y représente un groupement choisi parmi -CH2-, -(CH2) 2- et -CH=CH-, .cndot. ~R1 et R2, identiques ou différents, représentent chacun un atome d'hydrogène ou un groupement choisi parmi alkyle, cycloalkyle et cycloalkylalkyle, sous forme racémique ou d'isomères optiques, ainsi que leurs sels d'addition avec un acide pharmaceutiquement acceptable et leurs hydrates. Médicaments.
Brocco Mauricette
Millan Mark
Peglion Jean-Louis
Poitevin Christophe
Les Laboratoires Servier
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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