Tetracyclic indole derivatives as antiviral agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61K 31/553 (2006.01) A61P 31/12 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2621841

The present invention relates to tetracyclic indole derivatives of formula (I): wherein Ar, A, R1, R2, L, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.

La présente invention concern des dérivés d'indole tétracycliques représentés par la formule (I) dans laquelle Ar, A, R1, R2, L, W, X, Y et Z sont tels que définis dans la description, et des sels acceptables d'un point de vue pharmaceutique de ceux-ci, des compositions pharmaceutiques les contenant, et leur utilisation dans le traitement ou la prévention d'une infection par le virus de l'hépatite C.

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