Tetracyclic piperidino derivatives

Details Tetracyclic piperidino derivatives Tetracyclic piperidino derivatives

C - Chemistry, Metallurgy

07

D

260/200.1, 260/2

C07D 471/04 (2006.01) C07D 221/18 (2006.01)

Patent

CA 1053671

ABSTRACT OF THE DISCLOSURE The invention relates to novel biologically active tetracyclic piperidino derivatives of the general formula: Image I as well as the pharmaceutically acceptable salts and nitrogen oxides (N2) thereof, in which: R1 and R2 represent hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl, R3 stands for hydrogen, alkyl (1-6 C) or aralkyl (7-10 C), r and r' stand for the number 0, 1 or 2, X represents oxygen, sulphur, the group Image or methylene and R4 stands for hydrogen or alkyl (1-4 C). The novel compounds of the present invention are useful as tranquillizers which exhibit an anti-depressant effect.

219098

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