Tetracyclic progesterone receptor modulator compounds and...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 498/04 (2006.01) A61K 31/5383 (2006.01) A61P 5/32 (2006.01) A61P 35/00 (2006.01) C07D 265/00 (2006.01) C07D 311/00 (2006.01)

Patent

CA 2371273

Nonsteroidal compounds that are high affinity, high selectivity modulators for progesterone receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring progesterone receptor agonist, partial agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the progesterone receptor modulator compounds.

L'invention concerne des composés non stéroïdes qui sont des modulateurs à affinité et sélectivité élevées pour les récepteurs de progestérone, ainsi que des compositions pharmaceutiques renfermant lesdits composés. L'invention concerne en outre des procédés relatifs à l'utilisation de ces composés et de ces compositions pour le traitement de patients nécessitant une thérapie à base d'agoniste, d'agoniste partiel ou d'antagoniste de récepteur de progestérone, ainsi que des intermédiaires utiles dans la préparation des composés considérés et des procédés relatifs à l'élaboration des composés en question.

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