A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4162 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 209/82 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2516254
The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a tetracyclic pyrazole. The invention also provides specific tetracyclic pyrazole derivatives, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
La présente invention concerne un procédé pour traiter des maladies causées par une activité modifiée de protéine kinase et/ou associée à celle-ci; il consiste à administrer à un mammifère qui en a besoin une quantité efficace de pyrazole tétracyclique. L'invention porte aussi sur des dérivés de pyrazole tétracyclique, des intermédiaires utiles, une bibliothèque comprenant au moins un de ces dérivés, qui sont utiles traiter des maladies causées par une activité modifiée de protéine kinase et/ou associée à celle-ci, telles que le cancer, les troubles prolifératifs de cellules, les infections virales, les maladies auto-immunes et les troubles neuro-dégénératifs.
Cervi Giovanni
Ferguson Ron
Menichincheri Maria
Pulici Maurizio
Vanotti Ermes
Pharmacia & Italia S.p.a.
Smart & Biggar
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