Tetracyclic spiro-hydantoin aldose reductase inhibitors

Details Tetracyclic spiro-hydantoin aldose reductase inhibitors Tetracyclic spiro-hydantoin aldose reductase inhibitors

C - Chemistry, Metallurgy

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C07D 471/20 (2006.01) A61K 31/495 (2006.01) C07C 51/16 (2006.01) C07C 59/185 (2006.01) C07C 59/88 (2006.01) C07D 213/55 (2006.01) C07D 471/10 (2006.01)

Patent

CA 1255304

PC 6846 TETRACYCLIC SPIRO-HYDANTOIN ALDOSE REDUCTASE INHIBITORS Abstract Novel biologically-active tetracyclic spiro- hydantoin derivatives which are potent inhibitors of aldose reductase and useful in treating diabetic complications are disclosed. Pharmaceutical com- positions containing the novel compounds and a method of treating chronic diabetic complications are also disclosed. A preferred compound is 9'-chloro-5',6'-dihydro-2'-phenyl-spiro[imidazolidine- 5,7'-7'H-pyrido(1,2,3-de)quinoxaline]2,3',4-trione.

488544

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