Tetracyclic triterpenes

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 1/00 (2006.01) A61K 31/56 (2006.01) C07J 7/00 (2006.01) C07J 9/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2192789

Dammara compounds have immunosuppressant and anti-inflammatory activity and are useful as pharmaceuticals, particularly for use as immunosuppressant and anti-inflammatory agents. 17.alpha. dammara compounds are novel and are included per se, for example the compound of formula (IC) [(17.alpha.)-23-(E)- dammara-20,23-dien-3.beta.,25-diol], which may be obtained from the flour of the shoots of the Palmyrah palm, Borassus flabellifer L. In addition processes for the synthesis of this and other dammara compounds and intermediates thereof are described.

L'invention concerne des composés à action immunosuppressive et anti-inflammatoire destinés à être utilisés dans les produits pharmaceutiques, notamment sous forme d'agents immunosuppresseurs et anti-inflammatoires. Les composés de 17.alpha. dammara sont nouveaux et sont inclus en soi, par exemple le composé de formule (IC) [(17.alpha.)-23-(E)-dammara-20,23-dien-3.beta.,25-diol], qui peut être obtenu à partir de la farine issue des pousses du Borassus flabellifer L connu sous le nom du rônier. L'invention concerne en outre des procédés de synthèse desdits composés ainsi que d'autres composés dammara et de leurs intermédiaires.

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