Tetracycline repressor-mediated binary regulation system for...

Details Tetracycline repressor-mediated binary regulation system for... Tetracycline repressor-mediated binary regulation system for...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C07K 14/61 (2006.01) C12N 15/11 (2006.01) C12N 15/18 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2143326

The present invention relates to a tetracycline repressor-mediated binary regulation system for the control of gene expres- sion in transgenic animals. It is based, at least in part, on the discovery that, in a non-human transgenic animal that carries a first transgene under the control of a modified promoter comprising a tetR operator sequence and a second transgene encoding the tetR repressor protein, expression of the first transgene may be efficiently induced by administering tetracycline to the animal.

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