C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
195/101, 260/244
C07D 498/18 (2006.01) A61K 31/535 (2006.01) C12P 17/18 (2006.01)
Patent
CA 1248897
Abstract 1. Title of Invention: NEW TETRACYCLO COMPOUNDS, A PROCESS FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 2. New tetracyclo compounds of the formula : Image (I) in which R1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy or substituted iminomethyl, R2 is hydroxy, alkoxy or protected hydroxy, R3 is hydrogen and R4 is methyl, hydroxy- methyl or protected hydroxymethyl, or R3 and R4 are combined together to form methylene or oxo, R5 is hydroxy, alkoxy or protected hydroxy, and R6 is hydrogen, imino-protective group or alkyl, and pharmaceutically acceptable salts thereof, which have pharmacological activities such as antitumor activity, antimicrobial activity, and the like, and a process for their production and a pharmaceutical composition containing the same.
484513
Hashimoto Masashi
Iwami Morita
Kohsaka Masanobu
Komori Tadaaki
Takase Shigehiro
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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