Tetracyclononane derivatives

C - Chemistry – Metallurgy – 07 – C

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260/605.2, 260/6

C07C 217/84 (2006.01) C07C 211/19 (2006.01) C07C 211/48 (2006.01) C07C 211/52 (2006.01)

Patent

CA 1118792

Abstract of the Disclosure The invention relates to processes for preparing a new tetracyclononane derivative of the formula:- Image II wherein R1, R2 and R3 are hydrogen atoms or alkyl radicals and A is -CH2-CH2- or ? CH-R4 in which R4 is a hydroqen atom or an alkyl, cyclohexyl, phenyl-alkyl or optionally-substituted phenyl radical, or a pharmaceutically acceptable acid addition salt thereof, provided that when A is a radical of the formula ? CH-R4, at least one of R1, R2, R3 and R4 is other than a hydrogen atom; or a pharmaceutically-acceptable acid-addition salt thereof. Typical of the compounds disclosed is 8-(1-amino-ethyl)tetracyclo [4,3.0,02,4,- 03,7]nonane. The compounds are active against viruses such as the influenza viruses.

317203

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