Tetradotoxin insensitive sodium channel

Details Tetradotoxin insensitive sodium channel Tetradotoxin insensitive sodium channel

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2221294

The present invention relates to a novel 1,957 amino acid tetrodotoxin- insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.

La présente invention se rapporte à un nouveau canal sodique à 1957 acides aminés pouvant être soumis à une tension, insensible à la tétrodotoxine, ce canal étant spécifiquement placé dans les neurones sensitifs mammaliens. L'invention se rapporte également à des séquences nucléotidiques codant pour le nouveau canal sodique, à des vecteurs, à des cellules hôtes et à des procédés d'identification de modulateurs du nouveau canal sodique destiné à être utilisé dans le traitement de la douleur.

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