Tetraether lipid derivatives and liposomes and lipid...

Details Tetraether lipid derivatives and liposomes and lipid... Tetraether lipid derivatives and liposomes and lipid...

C - Chemistry, Metallurgy

07

D

C07D 323/00 (2006.01) A61K 9/127 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2269502

Conventional liposomes which are used for transporting pharmaceutical active agents in eukaryotic cells or for lipofection can only be preserved for a limited period, are not acid-stable and require a number of set parameters in order to achieve satisfactory results. Less sensitive liposomes are therefore highly desirable. The inventive tetraetherlipid derivatives are very stable and are well suited to lipofection.

Les liposomes classiques, utilisés pour véhiculer des principes actifs pharmaceutiques dans des cellules eucaryotes ou aux fins de lipofection, ont une durée de conservation limitée, une acidité instable et nécessitent la détermination de plusieurs paramètres pour pouvoir obtenir des résultats satisfaisants. Le développement de liposomes moins sensibles est donc souhaitable. Selon l'invention, on prépare des dérivés de tétraétherlipides qui sont très stables et parfaitement adaptés à la lipofection.

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