Tetrafluorobenzyl derivatives and pharmaceutical composition...

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 229/60 (2006.01) C07C 215/76 (2006.01) C07C 229/64 (2006.01) C07C 235/60 (2006.01) C07C 309/49 (2006.01)

Patent

CA 2490120

The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative diseases in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl derivative of the present invention can effectively be used to prevent and treat chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, degenerative brain disease such as epilepsy and ischemic brain disease such as stroke.

La présente invention se rapporte à un dérivé de tétrafluorobenzyle et à une composition pharmaceutique pour la prévention et le traitement de maladies neurodégénératives aiguës et chroniques affectant le système nerveux central ainsi que des maladies ophtalmiques contenant ledit dérivé. Ce dérivé de tétrafluorobenzyle de cette invention peut servir de manière efficace à éviter et traiter les maladies neurodégénératives chroniques, notamment la maladie d'Alzheimer, la maladie de Parkinson et la maladie d'Hungtington, le syndrome cérébral dégénératif, notamment l'épilepsie, et l'ischémie cérébrale, à savoir l'accident vasculaire cérébral.

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