Tetrahydro-2h-benzo [c] pyrroles

Details Tetrahydro-2h-benzo [c] pyrroles Tetrahydro-2h-benzo [c] pyrroles

C - Chemistry, Metallurgy

07

D

260/321

C07D 209/44 (2006.01)

Patent

CA 1117955

X-4658B Abstract of the Disclosure Novel tetrahydro-2H-benzo[c]pyrroles, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinson's syndrome, are described herein. These compounds are prepared by reacting a dl-5-amino-4,5,6,7-tetahydro- 2H-benzo[c]pyrrole with an aldehyde and then a reducing agent or with an alkyl halide, then an acyl halide followed by a reducing agent; and optionally with an alkyl halide and base. Also described are novel intermediates having the general formula Image IA wherein R1 is H or Image ; Am is NH2 or Image ; R3 is methyl, ethyl or n-propyl; except that R1 is not Image when Am is NH2; and the acid addition salts thereof when Am is NH2.

376468

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