Tetrahydro-(benzo or thieno)-azepine-pyrazine and triazine...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/04 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2432077

The invention relates to compounds which are represented by general formula (I) wherein R1~, R2~, R3~ R4~, X and Y are as defined in the specification, as well as pharmaceutically acceptable salts thereof. The invention further relates to medicaments containing these compounds and to a process for their preparation. The compounds possess affinity towards metabotropic glutamate receptors and are therefore useful in the treatment or prevention of acute and/or chronic neurological disorders.

L'invention concerne des composés qui sont représentés par la formule générale (I) où R<1>, R<2>, R<3> R<4>, X et Y sont définis dans la spécification, ainsi que comme étant des sels acceptables au plan pharmaceutique desdits composés. L'invention concerne également des médicaments contenant ces composés et une méthode pour leur préparation. Lesdits composés présentent une affinité pour les récepteurs métabotropiques de glutamate et sont par conséquent utiles dans le traitement ou la prévention de troubles neurologiques aigus et/ou chroniques.

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