Tetrahydro-.beta.-carboline compounds and use thereof

Details Tetrahydro-.beta.-carboline compounds and use thereof Tetrahydro-.beta.-carboline compounds and use thereof

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2560857

Tetrahydro-~ -carboline compounds represented by the following formulae: Wherein x, y and z are each independently an integer of 0 to 4 and R is selected from the group consisting of H, alkyl, aryl and heterocyclic moiety wherein the alkyl, aryl and heterocyclic moiety are optionally substituted with a member selected from the group consisting of halogen, alkoxy and trifluoromethyl; pharmaceutically acceptable salts thereof and prodrugs thereof are provided. The compounds are useful for treating neurological diseases.

Des composé de tétrahydro-.beta.-carboline présentés par les formules suivante:, 2 dans lesquelles x, y et z désignent, chacun pris indépendamment, un entier allant de 0 à 4 et R est sélectionné dans le groupe constitué de H, alkyle, aryle et une fraction hétérocyclique, où l'alkyle, l'aryle et la fraction hétérocyclique sont éventuellement substitués par un élément sélectionné dans le groupe constitué d'halogène, alcoxy et trifluorométhyle; leurs sels pharmaceutiquement acceptables et leurs promédicaments. Les composés sont utilisés pour le traitement de maladies neurologiques.

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