Tetrahydro-heterocycloazepinyl pyrimidine derivatives

Details Tetrahydro-heterocycloazepinyl pyrimidine derivatives Tetrahydro-heterocycloazepinyl pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 223/00 (2006.01) C07D 239/00 (2006.01) C07D 277/00 (2006.01) C07D 333/00 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2415966

The invention relates to compounds of the general formula (I) wherein HET and R1 to R12 have the significances as defined in the specification, as well as their phamaceutically acceptable salts. The invention further relates to medicaments containing such compounds and a process for the preparation of such compounds. The compounds of formula (I) are group (I) mGluR antagonists and are therefore useful for the control or prevention of acute and/or chronic neurological disorders.

L'invention concerne des composés représentés par la formule générale (I) dans laquelle HET et R?1¿ à R?12¿ sont tels que définis dans les revendications, ainsi que leurs sels acceptables d'un point de vue phamaceutique. L'invention concerne également des médicaments contenant ces composés et un procédé de préparation de ces composés. Les composés représentés par la formule (I) sont des antagonistes mGluR du groupe (I) et sont par conséquent utiles dans le contrôle ou la prévention des troubles neurologiques aigus et/ou chroniques.

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