C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/14 (2006.01) C07D 217/12 (2006.01)
Patent
CA 2707445
Disclosed are Tetrahydro-isoquinoline derivatives such as structural formula (I), pharmaceutical compositions comprising them and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like. Description of the variables in structural formula (I) are provided herein.
L'invention concerne des dérivés de tétrahydro-isoquinoline de formule structurale (I), des compositions pharmaceutiques les comprenant ainsi que des méthodes de traitement d'infections bactériennes. Les composés de l'invention sont des inhibiteurs de la PPAT (phosphopantéthéine adényltransférase), et sont utiles dans le traitement et la prévention de maladies provoquées par des bactéries, en particulier des bactéries dépendant de PPAT, par exemple, des espèces telles que Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, et analogues. La signification des variables de la formule structurale (I) est indiquée dans la description.
Biota Scientific Management Pty Ltd
Gowling Lafleur Henderson Llp
LandOfFree
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