Tetrahydro-midazo[1,5-.alpha.]pyrazine derivatives salts,...

Details Tetrahydro-midazo[1,5-.alpha.]pyrazine derivatives salts,... Tetrahydro-midazo[1,5-.alpha.]pyrazine derivatives salts,...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2753862

Pharmaceutical salts of (R)-7-[3-amino -4-(2,4,5-trifluorophenyl)-butyryl] -3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-.alpha.] pyrazine-1-formic acid, their preparation methods, compositions containing the said pharmaceutical salts and their use as medicaments, especially as dipeptidyl peptidase IV (DPP-IV) inhibitors are disclosed.

L'invention concerne des sels pharmaceutiques de l'acide (R)-7-[3-amino-4- (2,4,5-trifluorophényl)-butyryl]-3-trifluorométhyl-5,6,7,8-tétrahydro- imidazo[1,5-a]pyrazine-1-formique, leurs méthodes de préparation, des compositions contenant lesdits sels pharmaceutiques et leur utilisation en tant que médicaments, spécialement en tant qu'inhibiteurs de la dipeptidyl-peptidase IV (DPPIV).

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