Tetrahydrobenzazepine derivatives which inhibit lipoxygenase

Details Tetrahydrobenzazepine derivatives which inhibit lipoxygenase Tetrahydrobenzazepine derivatives which inhibit lipoxygenase

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2111460

Compounds of formula (I) wherein n is 1 to 5 and R is hydrogen, C1 to C4 alkyl, arylalkyl having from one to four car- bon atoms in the alkyl moiety or arylalkyl substituted with one or more substituents selected independently from the group consisting of halogen, nitro, cyano, C1 to C6 alkyl, C1 to C6 alcoxy, C1 to C6 halosubstituted alkyl, C1 to C6 hydroxysubstitut- ed alkyl, C2 to C7 alkoxycarbonyl and aminocarbonyl, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of li- poxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.

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