C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/82 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07D 235/00 (2006.01) C07D 263/00 (2006.01) C07D 263/58 (2006.01) C07D 277/00 (2006.01) C07D 277/68 (2006.01) C07D 277/72 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2415815
This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.
La présente invention concerne d'une façon générale, d'une part des analogues de tétrahydrobenzothiazole et des analogues de tétrahydrobenzooxyzole, d'autre part des compositions pharmaceutiques incluant ces composés et un vecteur pharmaceutiquement admis, et enfin des traitements utilisant ces composés. L'invention concerne également des esters, amides et sels pharmaceutiquement admis de tels composés. L'invention concerne enfin un procédé permettant de réduire ou de retarder l'apoptose dans une population de cellules. En effet, en mettant la population de cellules en contact avec un analogue de tétrahydrobenzothiazole ou un analogue de tétrahydrobenzooxyzole, on obtient une réduction ou un retard de l'apoptose dans la population de cellules considérée.
Greig Nigel H.
Holloway Harold Wayne
Mattson Mark
Yu Qian-Sheng
Zhu Xiaoxiang
Department Of Health & Human Services The Government Of The United States Of America As Represented By
Gowling Lafleur Henderson Llp
LandOfFree
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