C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/88 (2006.01) A61K 31/403 (2006.01) A61P 15/00 (2006.01) C07D 209/86 (2006.01) C07D 401/12 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2468880
Abstract: The invention relates to novel tetrahydrocarbozole derivatives acting as ligands for G-protein coupled receptors (GPCR), especially as antagonists of gonadotropin-releasing hormone (GnRH). The invention also relates to a pharmaceutical composition containing said novel tetrahydrocarbozole derivatives, and to a method for producing the same. Furthermore, the invention relates to the administration of tetrahydrocarbozole derivatives for the treatment of pathological conditions mediated by GPCR, especially for the inhibition of GnRH, to mammals, especially humans, requiring such treatment, and to the use of tetrahydrocarbozole derivatives for producing a pharmaceutical agent for treating pathological conditions mediated by GPCR, especially for the inhibition of GnRH. Image
La présente invention concerne de nouveaux dérivés tétrahydrocarbazol servant de ligands de récepteurs couplés aux protéines G (GPCR), notamment d'antagonistes de gonadolibérine (GnRH). L'invention concerne également une composition pharmaceutique contenant ces nouveaux dérivés tétrahydrocarbazol ainsi qu'un procédé de fabrication de ceux-ci. L'invention concerne par ailleurs l'administration de dérivés tétrahydrocarbazol pour le traitement de troubles à médiation par GPCR, notamment pour l'inhibition de GnRH, à des mammifères, notamment des humains, nécessitant un tel traitement, ainsi que l'utilisation de dérivés tétrahydrocarbazol pour la fabrication d'un agent pharmaceutique destiné au traitement de troubles à médiation par GPCR, notamment à l'inhibition de GnRH.
Hess-Stumpp Holger
Koppitz Marcus
Muhn Hans Peter
Paulini Klaus
Shaw Ken
Marks & Clerk
Zentaris Gmbh
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