Tetrahydrofuran derivatives and their use as nk-1 antagonists

Details Tetrahydrofuran derivatives and their use as nk-1 antagonists Tetrahydrofuran derivatives and their use as nk-1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 307/20 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2421869

The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 represent a variety of substituents; and pharmaceutically acceptable salts thereof.The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.

Cette invention, qui a trait à des composés correspondant à la formule I, dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿ et R?9¿ représentent divers substituants, concerne également leurs sels acceptables du point de vue pharmaceutique. Ces composés se révèlent des plus utiles pour le traitement ou la prévention de la dépression, de l'anxiété, de la douleur, des inflammations, de la migraine, des vomissements ou de l'algie post-zostérienne.

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