Tetrahydrofuranyl and tetrahydrothienyl substituted ethers

Details Tetrahydrofuranyl and tetrahydrothienyl substituted ethers Tetrahydrofuranyl and tetrahydrothienyl substituted ethers

C - Chemistry, Metallurgy

07

D

260/329.4, 260/3

C07D 307/16 (2006.01) C07C 35/38 (2006.01) C07C 51/367 (2006.01) C07C 62/32 (2006.01) C07D 307/12 (2006.01) C07D 307/87 (2006.01) C07D 309/12 (2006.01) C07D 317/24 (2006.01) C07D 319/08 (2006.01) C07D 333/24 (2006.01) C07D 407/04 (2006.01) C07D 407/12 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1253162

ABSTRACT TETRAHYDROFURANYL AND TETRAHYDROTHIENYL SUBSTITUTED ETHERS Tetrahydrofuranyl and tetrahydrothienyl substituted ethers are provided having the structural formula Image wherein A is (CH2)2, CH=CH or a single bond, m is 1 to 5, B is a single bond or CH=CH, n is 1 to 4, X is O or Image , wherein n' is 0, 1 or 2, R is H, lower alkyl or alkali metal and R1 is lower alkyl, arylalkyl, aryl, cycloalkyl, cycloalkylalkyl or lower alkenyl and including all stereoisomers thereof and Y is either oxygen or sulfur. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease and as antiinflammatory agents and analgesics.

480085

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