Tetrahydroimidazoquinazolinone cardiac stimulants

Details Tetrahydroimidazoquinazolinone cardiac stimulants Tetrahydroimidazoquinazolinone cardiac stimulants

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 213/64 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1270486

Abstract Title: "Tetrahydroimidazoquinazolinone Cardiac Stimulants" 1,2,3,5-Tetrahydroimidazo[2,1-b]quinazolin-2-(1H)-one cardiac stimulants, and their pharmaceutically acceptable salts, of the formula:- Image (I) wherein "Het" is an optionally substituted 5- or 6-membered aromatic heterocyclic group attached to the 6-, 7-, 8-, or 9-position of said 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-(1H)-one; R, which is attached to the 6-, 7-, 8- or 9-position, is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, hydroxymethyl, halo or CF3; and R1, R2, R3, R4 and R5 are each H or C1-C4 alkyl.

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