Tetrahydroindolone and purine derivatives linked to...

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 25/18 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2455987

Pharmaceutical composite compositions comprising tetrahydroindolones linked to arylpiperazines and derivatives thereof are disclosed. Specifically, composite compositions useful in treating anti-psychotic disorders are disclosed. The composite compositions disclosed herein can effectively ameliorate symptoms and treat psychotic disorders without causing a decrease in cognitive function. Generally, the composite compounds consist of two moieties, moiety A and B in which a tetrahydroindolone comprises a moiety A linked through a linker L to a moiety B, where B is an arylpiperazinyl moiety. The composite compound provides anti-psychotic actively by interaction with GABA, seratoninne and dopamine receptors. The composite molecules with the combined activities will provide treat psychiatric and neurological diseases without cognitive impairment.

L'invention concerne des compositions pharmaceutiques composites comprenant des tétrahydroindolones liées à des arylpipérazines et des dérivés de ces produits. Elle concerne, plus spécifiquement, des compositions composites utiles dans des traitements antipsychotiques. Les compositions composites de l'invention peuvent effectivement améliorer les symptômes et traiter des troubles psychotiques sans provoquer de réduction de la fonction cognitive. Les composés composites sont constitués, généralement, de deux entités A et B dans lesquelles une tétrahydroindolone comprend un groupe A lié, par un bras lieur, à un groupe B, le groupe B étant une entité arylpipérazinyle. Le composé composite possède une activité antipsychotique au travers de son interaction avec des récepteurs de GABA, de sérotonine et de dopamine. Les molécules composites avec leurs activités combinées permettent de traiter des troubles psychiatriques et neurologiques sans créer de déficience intellectuelle.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Tetrahydroindolone and purine derivatives linked to... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrahydroindolone and purine derivatives linked to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrahydroindolone and purine derivatives linked to... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1548041

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.