Tetrahydroisoquinolin-1-one derivative or salt thereof

Details Tetrahydroisoquinolin-1-one derivative or salt thereof Tetrahydroisoquinolin-1-one derivative or salt thereof

C - Chemistry, Metallurgy

07

D

C07D 217/26 (2006.01) A61K 31/472 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61K 31/695 (2006.01) A61P 1/00 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2688326

[PROBLEMS] To provide a compound which can be used as a medicinal agent, particularly a therapeutic agent for irritable bowel syndrome (IBS). [MEANS FOR SOLVING PROBLEMS] It is found that a tetrahydroisoquinolin-1-one derivative having an amide group at position-4 or a pharmaceutically acceptable salt thereof has an excellent antagonistic activity on a bombesin-2 (BB2) receptor. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on stool abnormality. Therefore, the tetrahydroisoquinolin-1-one derivative is useful as a therapeutic agent for a disease associated with a BB2 receptor, particularly IBS.

L'invention vise à proposer un composé qui peut être utilisé comme agent médical, en particulier un agent thérapeutique pour le syndrome du côlon irritable (IBS). Il a été découvert qu'un dérivé de tétrahydroisoquinolin-1-one ayant un groupe amide en position 4 ou un sel pharmaceutiquement acceptable de celui-ci présente une excellente activité antagoniste sur un récepteur de bombésine-2 (BB2). Il a également été découvert que le dérivé de tétrahydroisoquinolin-1-one est hautement efficace sur une anomalie des selles. Par conséquent, le dérivé de tétrahydroisoquinolin-1-one est utile comme agent thérapeutique pour une maladie associée à un récepteur BB2, en particulier l'IBS.

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