Tetrahydroisoquinoline analogs useful as growth hormone...

C - Chemistry – Metallurgy – 07 – D

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C07D 217/26 (2006.01) A61K 31/472 (2006.01) A61P 3/00 (2006.01) C07D 209/44 (2006.01) C07D 223/16 (2006.01) C07D 417/12 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2408486

Tetrahydroisoquinoline analogs are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The tetrahydroisoquinoline analogs thereof have the structure (I) wherein R1, R2, R3, R3a, X1, X2, X3, X4, m and n are as described herein.

L'invention concerne des analogues de tétrahydroisoquinoline qui peuvent servir à stimuler la production endogène ou la libération d'hormones de croissance et à traiter l'obésité, l'ostéoporose (par amélioration de la densité osseuse) et à améliorer la masse et la force musculaires. Ces analogues de tétrahydroisoquinoline présente la structure suivante dans laquelle R¿1?, R¿2?, R¿3?, R¿3a?, X¿1?, X¿2?, X¿3?, X¿4?, m et n sont tels que spécifiés dans le descriptif.

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