Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives...

Details Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives... Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives...

C - Chemistry, Metallurgy

07

D

C07D 217/14 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 35/00 (2006.01) C07D 217/16 (2006.01) C07D 233/16 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2555745

Compounds of the formula (I): where R2, R5, R6 have the meanings as given in the description, and U, V and W, respectively, may be CR2', CR4' and CR6', respectively (with the definitions of R2', R4' and R6' again as in the description), or may be N, were io synthesized. They were found to down- regulate or inhibit the expression or function of the IGF-1 receptor.

L'invention concerne des composés de formule (I): dans laquelle R2, R5, R6 ont la signification indiquée dans la description, et U, V et W, peuvent représenter respectivement CR2', CR4' et CR6', (R2', R4' et R6' étant définis dans la description), ou peuvent représenter N, lesdits composés étant synthétisés. On a découvert que ces composés régulent négativement ou inhibent l'expression ou la fonction du récepteur de l'IGF-1.

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