Tetrahydroisoquinolinyl-indole derivatives for the treatment...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/06 (2006.01) A61K 31/4725 (2006.01) A61P 25/24 (2006.01) A61P 43/00 (2006.01) C07D 401/08 (2006.01)

Patent

CA 2370241

Compounds are provided which have formula (I) wherein: R1, R2, R3, and R4 are, independently, hydrogen, halogen, alkoxy, or carboxamide; R5 is hydrogen, halogen, CF3, CN, carbamide or alkoxy; and X is (CH2)n or a 4-6 membered carbocyclic ring, wherein n is an integer of 2 to 4; or pharmaceutically acceptable salts thereof.

La présente invention concerne des composés de formule (I) dans laquelle: R¿1?, R¿2?, R¿3? et R¿4? représentent, indépendamment, l'hydrogène, halogène alcoxy, ou carboxamide; R¿5? représente l'hydrogène, halogène, CF¿3?, CN, carbamide ou alcoxy; et X représente (CH¿2?)¿n? ou un noyau carbocyclique en C¿4?-C¿6?, où n est un nombre entier compris entre 2 et 4; ou leurs sels pharmaceutiquement acceptables.

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