Tetrahydronaphthalene derivatives

Details Tetrahydronaphthalene derivatives Tetrahydronaphthalene derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/239

C07D 235/04 (2006.01) C07D 233/54 (2006.01) C07D 235/14 (2006.01) C07D 235/26 (2006.01) C07D 243/14 (2006.01) C07D 277/64 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1319144

Abstract It has been found that the novel tetrahydronaphthaiene derivatives of the formula Image I wherein the symbols A, X, n. R, R1 R2 and R3 have the significance given in claim 1. have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pactoris, ischaemia, arrhythmias. high blood pressure and cardiac insufficiency. The compounds of formula I can be manufactured by aminating a compound of the formula Image II with a corresponding N-alkylamine and optional subsequent O-acylation or reaction with an isocyanate and N-oxidation.

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