Tetrahydronaphthalene derivatives

Details Tetrahydronaphthalene derivatives Tetrahydronaphthalene derivatives

C - Chemistry, Metallurgy

07

C

167/243, 167/255

C07C 219/24 (2006.01) A61K 31/22 (2006.01) A61K 31/335 (2006.01) C07C 35/52 (2006.01) C07C 57/58 (2006.01) C07C 57/76 (2006.01) C07D 307/68 (2006.01) C07D 317/58 (2006.01) C07D 317/60 (2006.01) C07D 319/18 (2006.01)

Patent

CA 2011461

Abstract It has been found that the novel tetrahydronaphthalene derivatives of the formula Image I wherein R1 to R6 and n have the significance given in claim 1. have a pronounced activity in counteracting cerebral insufficiency or improving cognitive functions and also reduce the multiple-resistance towards cytostatics in the treatment of tumours or of chloroquine resistance in the treatment of malaria. They can accordingly be used as medicaments, especially for the control or prevention of cerebral insufficiency or for the improvement of cognitive functions. The novel compounds of formula I can be manufactured by O-acylating a likewise novel compound of the formula Image II.

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