Tetrahydronaphthalene derivatives and preparation thereof

Details Tetrahydronaphthalene derivatives and preparation thereof Tetrahydronaphthalene derivatives and preparation thereof

C - Chemistry, Metallurgy

07

C

167/179, 260/329

C07C 311/00 (2006.01) A61K 31/00 (2006.01) C07C 229/50 (2006.01) C07C 311/07 (2006.01) C07C 311/14 (2006.01) C07C 311/20 (2006.01) C07C 311/29 (2006.01) C07D 213/71 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2030004

Abstract The present invention is directed to a tetrahydronaphthalene derivative of the formula: Image (I) wherein R1 is a substituted or unsubstituted phenyl group, a naphthyl group, a sulfur- or nitrogen-containing heterocyclic group, a lower alkyl group or cycloalkyl group, and R2 is a hydroxymethyl group, a carboxyl group, a lower alkoxycarbonyl group or a group of the formula: Image wherein R3 is a hydrogen atom or a lower alkyl group, R4 is a lower alkoxycarbonyl-phenyl group, a carboxy-phenyl group, a lower alkyl group, a lower alkoxycarbonyl-lower alkyl group or a carboxy-lower alkyl group, and m and n are different and are integers of 1 or 2, or a pharmaceutically acceptable salt thereof. The derivatives of the present invention are useful as platelet aggregation-inhibiting agents and as agents for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like. The invention is further directed to processes for the preparation of the derivatives, and to pharmaceutical compositions containing the derivatives as an active ingredient.

Affiliated with

Also associated with

Rating

Tetrahydronaphthalene derivatives and preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrahydronaphthalene derivatives and preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrahydronaphthalene derivatives and preparation thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1464917