Tetrahydronaphthalene derivatives as dopamine agonists

Details Tetrahydronaphthalene derivatives as dopamine agonists Tetrahydronaphthalene derivatives as dopamine agonists

C - Chemistry, Metallurgy

07

D

167/209, 167/215

C07D 265/34 (2006.01) A61K 31/53 (2006.01) A61K 31/55 (2006.01) C07D 267/12 (2006.01) C07D 267/16 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 1264741

TETRAHYDRONAPHTHALENE DERIVATIVES AS DOPAMINE AGONISTS ABSTRACT OF THE DISCLOSURE Disclosed are compounds of the formula: Image wherein: R1 is H, OH, -OCH3, -CH2OH, -NH2, -NHCH3, -NHCH2CH3, -N(CH3)2, -N(CH2CH3)2, Image , HN?CH3, halogen, or -O?-R3; R2 is H, -CH3, or -?-R3; R3 is phenyl, benzyl, or 1-4 carbon alkyl; R4 is H, -CH3, -CH2OH, -CH2-CN, -CH2-S-CH3, -CH2-S-CN, or Image ; R5 is H, 1-4 carbon alkyl, alkenyl, or alkynyl, or aralkyl having a 1-4 carbon alkylene moiety, propargyl, 2- thienylethyl or 3-thienylethyl, provided that when R4 is H or -CH3, R5 is propargyl, 2-thienylethyl or 3-thienylethyl; and A is -CH2- or -CH2CH2, their preparation pharmaceutical compositions containing them and their use as dopamine agonists.

478967

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