C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/00 (2006.01)
Patent
CA 2560008
The present invention is directed to a novel compound of the formula (I): Image wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independently hydrogen; alkyl, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).
Il est prévu un nouveau composé de la formule (I) : où R1 est un alkoxycarbonyle ou autre, R2 est un alkyle ou autre; R3 est un hydrogène ou autre ; R4 est un alkylène ou autre ; R5 est un groupe hétérocyclique substitué en option ; R6, R7 et R8 sont indépendamment de l'hydrogène ; un alkyle, un alkoxy, ou autre ; R10 est un anneau aromatique substitué en option, ou autre ; ou un sel acceptable pharmaceutiquement de celui-ci, ayant une activité inhibitoire contre la protéine de transfert d~ester cholestéryle (CETP).
Higashijima Takanori
Igarashi Shigeki
Kubota Hitoshi
Nakamura Yoshinori
Oka Kozo
Kirby Eades Gale Baker
Mitsubishi Tanabe Pharma Corporation
Tanabe Seiyaku Co. Ltd.
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