C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/12 (2006.01) A61K 31/473 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2716726
The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of Formula (I) wherein R1, R2, R3, R 4, R5, R6, R7 and Y have defined meanings.
La présente invention porte sur des composés représentés par la formule (I), sur leur utilisation comme inhibiteurs de la polymérisation de la tubuline et sur leur utilisation comme inhibiteurs de PARP ainsi que sur des compositions pharmaceutiques comprenant lesdits composés représentés par la formule (I), dans laquelle R1, R2, R3, R 4, R5, R6, R7 et Y ont les significations telles que définies dans la description.
Angibaud Patrick Rene
Mevellec Laurence Anne
Meyer Christophe
Roux Bruno
Storck Pierre-Henri
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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