Tetrahydropyran nucleic acid analogs

Details Tetrahydropyran nucleic acid analogs Tetrahydropyran nucleic acid analogs

C - Chemistry, Metallurgy

07

H

C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2696497

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

L'invention concerne des analogues de tétrahydropyrane nucléoside, des composés oligomères préparés à partir de ceux-ci et des procédés d'utilisation des composés oligomères. Plus particulièrement, des analogues de tétrahydropyrane nucléoside sont proposés, ayant un ou plusieurs substituants chiraux, qui sont utiles pour améliorer les propriétés des composés oligomères comprenant la résistance aux nucléases et l'affinité de liaison. Dans certains modes de réalisation, les composés oligomères proposés ici s'hybrident sur une partie d'un ARN cible entraînant une perte du fonctionnement normal de l'ARN cible.

Affiliated with

Also associated with

Rating

Tetrahydropyran nucleic acid analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrahydropyran nucleic acid analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrahydropyran nucleic acid analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1759200