C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01)
Patent
CA 2483752
The present invention is directed to compounds of the formula (I): (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
L'invention concerne des composés de formule I (dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, X, n et la ligne pointillée sont tels que définis dans la description). Ces composés sont utilisés en tant que modulateurs de l'activité des récepteurs de chimiokine. Les composés selon l'invention sont particulièrement utiles en tant que modulateurs du récepteur CCR-2 de chimiokine.
Butora Gabor
Goble Stephen D.
Guiadeen Deodialsingh
Jiao Richard
Kothandaraman Shankaran
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Merck Sharp & Dohme Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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