Tetrahydropyridine derivative and cardiotonic agent...

Details Tetrahydropyridine derivative and cardiotonic agent... Tetrahydropyridine derivative and cardiotonic agent...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/50 (2006.01) A61K 31/53 (2006.01) A61K 31/54 (2006.01) C07D 405/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2124584

Disclosed are a novel heterocyclic compound of the formula (I): (see Formula I) (in which R and R1 are each hydrogen or lower alkyl; R2 and R3 are each hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, halogen, nitro, amino, cyano or hydroxyl or together form methylenedioxy or (see Formula II) forms naphthalene; and A-E represents -S-CR4R5-, -CH2-S-, -NH-CH2- or -CH2CH2- wherein R4 and R5 are each hydrogen or lower alkyl) having excellent positive inotropic effect as cardiotonic agent and suppressing increase of heart rate; and a cardiotonic agent containing the novel heterocyclic compound as active component.

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