C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2596501
The invention relates to compounds of formula (I) wherein Ra is -C(O)ORI, in which R1 is 1-7C-a.kyl. 3-7C-cycoakyl, 1-7C-alkyl substituted by Raa, or 2-7C- alky substituted by Rab and Rac on different carbon atoms, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and Q is substituted by Rba and Rbb and Rbc, and is phenyl, wich are useful for the therapy of hyperprolif erative diseases, in particular human cancer.
La présente invention se rapporte à des composés de formule (I) dans laquelle Ra est -C(O)ORI, où R1 est un alkyle en C1-7, un cycloalkyle en C3-7, un alkyle en C1-7 portant une substitution Raa ou un alkyle en C2-7 portant des substitutions Rab et Rac sur différents atomes de carbone, et Rb est -T-Q, où T est un alkylène en C1-6 ou un cycloalkylène en C3-7 et Q est un phényle portant des substitutions Rba, Rbb et Rbc. Ces composés sont utiles pour le traitement des maladies hyperprolifératives, en particulier le cancer humain.
Baer Thomas
Bartels Bjoern
Beckers Thomas
Pekari Klaus
Schmidt Mathias
4sc Ag
Altana Pharma Ag
Gowling Lafleur Henderson Llp
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